Role for gamma-aminobutyric acid in selective vulnerability in gerbils.
نویسندگان
چکیده
منابع مشابه
Role for y-Aminobutyric Acid in Selective Vulnerability in Gerbils
We tested the efficacy of various putative neuroprotective agents in the gerbil model of delayed neuronal death. The selective loss of anterior CA1 neurons of the hippocampus 4 days after 5 minutes of bilateral ischemia was complete in >90% of the gerbils examined. We tested 11 agents for their ability to protect against neuronal loss. Only those agents that were associated with the GABAergic s...
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Gamma aminobutyrate (GABA) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. Mechanisms by which GABA may facilitate these responses to stress are metabolic and/or mechanical disruptions. Environmental stresses increase GABA accumulation through cytosolic acidification, induce an acidic pH-dependent activation of glutamate...
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Introduction Gamma-aminobutyric acid (GABA) is a major neuro transmitter widely distributed throughout the central nervous system (CNS). Because too much excitation can lead to irritability, restlessness, insomnia, seizures, and movement disorders, it must be balanced with inhibition. GABA – the most important inhibitory neurotransmitter in the brain – provides this inhibition, acting like a “b...
متن کاملp146: gamma aminobutyric acid (gaba) and its alterations in stress
gamma aminobutyrate (gaba) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. mechanisms by which gaba may facilitate these responses to stress are metabolic and/or mechanical disruptions. environmental stresses increase gaba accumulation through cytosolic acidification, induce an acidic ph-dependent activation of glutamate...
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ژورنال
عنوان ژورنال: Stroke
سال: 1989
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.20.2.281